DRUGS
Digitalis and guanethidine decreases the heart rate.

Guanethidine increses the effects of direct-acting sympathomimetics (norepinephrine).

Alpha blocking agents, beta blocking agents, or reserpine likely will increase the effect of guanethidine.

Over the counter (OTC) medications for treatment of colds, allergies, and asthma containing sympathomimetics should not be taken without physician's advice.

DECREASES THE HYPOTENSIVE EFFECT OF GUANETHIDINE:
    a. - Amphetamine-like compounds
    b. - stimulants (e.g., ephedrine, methylphenidate)
    c. - Tricyclic antidepressants (e.g., amitriptyline, imipramine, desipramine)
    d. - Psychopharmacologic agents (e.g., phenothiazines and related compounds)
    e. - Oral contraceptives
    f. - Haloperidol
    g. - Methylphenidate
    h. - MAO inhibitors
    i. - Indirect-acting sympathomimetics (ephedrine, phenylpropanolamine).
    j. - Thioxanthenes
 

INCREASES THE HYPOTENSIVE EFFECT OF GUANETHIDINE:
    a. - Thiazide diuretics
    b. - Minoxidil

FOODS

LAB TESTS

OTHERS
The patient should be cautioned about ingesting alcohol, since it aggravates the orthostatic hypotensive effects of guanethidine.

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