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PHARMACOLOGY

guanadrel

Guanadrel inhibit norepinephrine release from sympathetic nerve endings (peripheral). It also depletes the tissue stores of catecholamines (epinephrine and norepinephrine) from sympathetic nerve endings (peripheral).
This results in a decreased in the heart rate and a decrease in peripheral resistance which lowers blood pressure.

Fluid retention occurs with th use of guanadrel.

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